Copine-4 is a protein that in humans is encoded by the CPNE4 gene .[ 5] [ 6] [ 7]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm .
This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000196353 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032564 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans" . J Biol Chem . 273 (3): 1393–402. doi :10.1074/jbc.273.3.1393 PMID 9430674 . ^ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8" . Biochem Biophys Res Commun . 303 (3): 842–7. doi :10.1016/S0006-291X(03)00445-5 . PMID 12670487 . ^ a b "Entrez Gene: CPNE4 copine IV" .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif" . J. Biol. Chem . 278 (12): 10048–54. doi :10.1074/jbc.M212632200 PMID 12522145 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
