Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[5][6][7]

CUL7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDsOMIM: 609577; MGI: 1913765; HomoloGene: 56683; GeneCards: CUL7; OMA:CUL7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001168370
NM_014780
NM_001374872
NM_001374873
NM_001374874

NM_025611

RefSeq (protein)

NP_001161842
NP_055595
NP_001361801
NP_001361802
NP_001361803

NP_079887

Location (UCSC)Chr 6: 43.04 – 43.05 MbChr 17: 46.96 – 46.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

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It is associated with 3-M syndrome.

Interactions

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CUL7 has been shown to interact with RBX1.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000044090Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038545Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  6. ^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. Bibcode:2003PNAS..100.9855A. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
  7. ^ "Entrez Gene: CUL7 cullin 7".

Further reading

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