DGKG

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.

DGKG
Identifiers
Aliases	DGKG, DAGK3, DGK-GAMMA, diacylglycerol kinase gamma
External IDs	OMIM: 601854; MGI: 105060; HomoloGene: 1029; GeneCards: DGKG; OMA:DGKG - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.2-q27.3 Start 186,105,668 bp End 186,362,234 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B1|16 13.37 cM Start 22,287,211 bp End 22,475,971 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum buccal mucosa cell gastric mucosa monocyte cingulate gyrus anterior cingulate cortex left ventricle apex of heart Top expressed in subiculum dentate gyrus of hippocampal formation granule cell lobe of cerebellum lateral septal nucleus hippocampus proper cerebellar vermis granulocyte anterior amygdaloid area piriform cortex pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytoplasm plasma membrane membrane Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction neuron development phosphorylation glycerolipid metabolic process lipid phosphorylation metabolism signal transduction diacylglycerol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1608 110197 Ensembl ENSG00000058866 ENSMUSG00000022861 UniProt P49619 Q91WG7 RefSeq (mRNA) NM_001346 NM_001080744 NM_001080745 NM_138650 NM_001346673 RefSeq (protein) NP_001074213 NP_001074214 NP_001337 NP_001333602 NP_619591 Location (UCSC) Chr 3: 186.11 – 186.36 Mb Chr 16: 22.29 – 22.48 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Brose N, Betz A, Wegmeyer H (2004). "Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals". Curr. Opin. Neurobiol. 14 (3): 328–40. doi:10.1016/j.conb.2004.05.006. PMID 15194113. S2CID 7070625.
• Luo B, Regier DS, Prescott SM, Topham MK (2005). "Diacylglycerol kinases". Cell. Signal. 16 (9): 983–9. doi:10.1016/j.cellsig.2004.03.016. PMID 15212759.
• Topham MK (2006). "Signaling roles of diacylglycerol kinases". J. Cell. Biochem. 97 (3): 474–84. doi:10.1002/jcb.20704. PMID 16288460. S2CID 38850368.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Yamada K, Sakane F, Matsushima N, Kanoh H (1997). "EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes". Biochem. J. 321. ( Pt 1) (Pt 1): 59–64. doi:10.1042/bj3210059. PMC 1218036. PMID 9003401.
• Stöhr H, Klein J, Gehrig A, et al. (1999). "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)". Hum. Genet. 104 (1): 99–105. doi:10.1007/s004390050917. PMID 10071200. S2CID 19248400.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamada K, Sakane F, Imai S, et al. (2003). "Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells". Biochem. Biophys. Res. Commun. 305 (1): 101–7. doi:10.1016/S0006-291X(03)00713-7. PMID 12732202.
• Oyaizu K, Kantarci A, Maeda H, et al. (2003). "Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis". J. Periodont. Res. 38 (5): 488–95. doi:10.1034/j.1600-0765.2003.00680.x. PMID 12941073.
• Tsushima S, Kai M, Yamada K, et al. (2004). "Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation". J. Biol. Chem. 279 (27): 28603–13. doi:10.1074/jbc.M314031200. PMID 15102830.
• Filosto M, Mancuso M, Tomelleri G, et al. (2004). "Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation". Acta Neuropathol. 108 (2): 168–71. doi:10.1007/s00401-004-0872-9. PMID 15150663. S2CID 31732164.
• Batista EL, Warbington M, Badwey JA, Van Dyke TE (2005). "Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs)". J. Cell. Biochem. 94 (4): 774–93. doi:10.1002/jcb.20356. PMID 15578578. S2CID 114877.
• Matsubara T, Shirai Y, Miyasaka K, et al. (2006). "Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus". J. Biol. Chem. 281 (10): 6152–64. doi:10.1074/jbc.M509873200. hdl:20.500.14094/D1004334. PMID 16407189.
• Yamaguchi Y, Shirai Y, Matsubara T, et al. (2006). "Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma". J. Biol. Chem. 281 (42): 31627–37. doi:10.1074/jbc.M606992200. hdl:20.500.14094/D2003002. PMID 16905533.