Daf-5 is an ortholog of the mammalian protein Sno/Ski，which present in the nematode worm Caenorhabditis elegans on the downstream of TGFβ signaling pathway.[1] Without daf-7 signal, daf-5 combined with daf-3, co-SMAD for C. elegans, to form a heterodimer and started dauer development.[2]
| Dauer Formation abnormality gene 5 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Daf-5 | ||||||
| Entrez | 175054 | ||||||
| RefSeq (mRNA) | NM_064540.5 | ||||||
| RefSeq (Prot) | NP_496941.1 | ||||||
| UniProt | G5EDM7 | ||||||
| Other data | |||||||
| Chromosome | II: 14.03 - 14.04 Mb | ||||||
| |||||||
References
edit- ^ da Graca LS, Zimmerman KK, Mitchell MC, Kozhan-Gorodetska M, Sekiewicz K, Morales Y, Patterson GI (January 2004). "DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development". Development. 131 (2): 435–46. doi:10.1242/dev.00922. PMID 14681186. S2CID 31708102.
- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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