This article relies largely or entirely on a single source. (July 2020) |
The DAF-3 or Dwarfin sma is a nematode Caenorhabditis elegans gene encoding a Co-SMAD protein of TGF-beta signaling pathway. Without daf-7 signal, DAF-3 combined with transcription factor daf-5 to form a heterodimer and started dauer development. When daf-7 binds to the receptors daf-1/daf-4, the phosphorylated daf-8/daf-14 heterodimer enter to the nucleus to inhibit this transcription.[1]
Dwarfin sma | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | daf-3 | ||||||
Entrez | 180431 | ||||||
RefSeq (mRNA) | NM_075760.6 | ||||||
RefSeq (Prot) | NP_508161.3 | ||||||
UniProt | Q95QI7 | ||||||
Other data | |||||||
Chromosome | X: 0.82 - 0.83 Mb | ||||||
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References
edit- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.