The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.[1] When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[2]
| Dwarfin sma | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-8 | ||||||
| Entrez | 187612 | ||||||
| RefSeq (mRNA) | NM_059920.3 | ||||||
| RefSeq (Prot) | NP_492321.1 | ||||||
| UniProt | Q21733 | ||||||
| Other data | |||||||
| Chromosome | I: 8.58 - 8.59 Mb | ||||||
| |||||||
References
edit- ^ Li FF, Gasser RB, Liu F, Shan JN, Di WD, He L, et al. (April 2020). "Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus". Parasites & Vectors. 13 (1): 164. doi:10.1186/s13071-020-04034-0. PMC 7119156. PMID 32245505.
- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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