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The DAF-14 is a gene of the nematode Caenorhabditis elegans encoding a R-SMAD protein of TGF-beta signaling pathway, which will be phosphorylated and forms a heterodimer with phosphorylated daf-8 when the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4, then the heterodimer enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[1]
| MH2 domain-containing protein | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-14 | ||||||
| Entrez | 177908 | ||||||
| RefSeq (mRNA) | NM_001268546.3 | ||||||
| RefSeq (Prot) | NP_001255475.1 | ||||||
| UniProt | G5EEP2 | ||||||
| Other data | |||||||
| Chromosome | IV: 10.25 - 10.26 Mb | ||||||
| |||||||
References
edit- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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