The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans.[1] DAF-1 is one of the type I receptor of TGF-beta pathway.[2] DAF-1 acts as a receptor protein serine/threonine kinase, is activated by type II receptor Daf-4 phosphorylation after the ligand Daf-7 binds to the receptor heterotetramer, and then phosphorylates Daf-8 or Daf-14, the SMAD proteins in C. elegans.[3]
| abnormal dauer formation protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-1 | ||||||
| Entrez | 176829 | ||||||
| HomoloGene | 134382 | ||||||
| UniProt | P20792 | ||||||
| Other data | |||||||
| Chromosome | IV: 0.13 - 0.14 Mb | ||||||
| |||||||
References
edit- ^ Georgi LL, Albert PS, Riddle DL (May 1990). "daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase". Cell. 61 (4): 635–45. doi:10.1016/0092-8674(90)90475-t. PMID 2160853. S2CID 205020137.
- ^ Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6284–8. Bibcode:2001PNAS...98.6284M. doi:10.1073/pnas.111409798. PMC 33460. PMID 11353865.
- ^ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.