Dimethoxytrityl, often abbreviated DMT, is a protecting group widely used for protection of the 5'-hydroxy group in nucleosides, particularly in oligonucleotide synthesis.[1]
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IUPAC name
bis(4-methoxyphenyl)-phenylmethyl radical
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Other names
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Identifiers | |
3D model (JSmol)
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PubChem CID
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Properties | |
C21H19O2 | |
Molar mass | 303.4 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is usually bound to a molecule, but can exist as a stable cation in solution, where it appears bright orange.[2]
References
edit- ^ Krotz, Achim; Cole, Douglas; Ravikumar, Vasulinga (1999). "Dimethoxytrityl Removal in Organic Medium: Efficient Oligonucleotide Synthesis Without Chlorinated Solvents". Nucleosides and Nucleotides. 18 (6–7): 1207–1209. doi:10.1080/07328319908044664.
- ^ "Dimethoxytrityl/DMT (Orange you glad you protected that alcohol?)". Molecule of the Day. 2006-09-05. Retrieved 2022-05-03.