ENTPD3

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.

ENTPD3
Identifiers
Aliases	ENTPD3, CD39L3, HB6, NTPDase-3, ectonucleoside triphosphate diphosphohydrolase 3
External IDs	OMIM: 603161; MGI: 1321386; HomoloGene: 68171; GeneCards: ENTPD3; OMA:ENTPD3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.1 Start 40,387,184 bp End 40,428,744 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F4 Start 120,368,884 bp End 120,397,393 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans periodontal fiber middle temporal gyrus parotid gland putamen nasal epithelium tibia caudate nucleus minor salivary glands decidua Top expressed in molar islet of Langerhans vestibular membrane of cochlear duct facial skeleton transitional epithelium of urinary bladder body of femur lesser wing of sphenoid bone membranous bone Dermatocranium lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding nucleoside-diphosphatase activity nucleoside-triphosphatase activity Cellular component integral component of membrane membrane plasma membrane Biological process nucleoside triphosphate catabolic process nucleoside diphosphate catabolic process nucleobase-containing small molecule catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 956 215446 Ensembl ENSG00000168032 ENSMUSG00000041608 UniProt O75355 Q8BFW6 RefSeq (mRNA) NM_001248 NM_001291960 NM_001291961 NM_178676 RefSeq (protein) NP_001239 NP_001278889 NP_001278890 NP_848791 Location (UCSC) Chr 3: 40.39 – 40.43 Mb Chr 9: 120.37 – 120.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.

Further reading

• Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists". Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
• Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling". Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions". Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
• Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase". Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
• Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1". Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
• Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.