Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene.[5] The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

FANCD2OS
Identifiers
AliasesFANCD2OS, C3orf24, FANCD2 opposite strand
External IDsMGI: 1918229; HomoloGene: 45456; GeneCards: FANCD2OS; OMA:FANCD2OS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173472
NM_001164839

NM_027633

RefSeq (protein)

NP_001158311
NP_775743

NP_081909

Location (UCSC)Chr 3: 10.08 – 10.11 MbChr 6: 113.57 – 113.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

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The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length.[6] The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.[5]

mRNA

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There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage.[7] The most common isoform is 1105 bp.[8]

Promoter Region

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The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

Regulatory

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Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

Expression

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FANCD2OS is moderately expressed in the human brain, placenta and testes.[9]

Evolutionary History

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Protein sequence

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The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.[10]

Orthologs

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Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark.[11] The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

Species Common name NCBI accession Identity similarity E-value
Pongo abelii Sumatran orangutan XP_003776240.1 98.9 99.4 1.21E-133
Cricetulus griseus Chinese hamster XP_003511850.1 73.6 80.9 1.56E-95
Ovis aries Sheep XP_004018322.1 97.2 98.3 6.79E-131
Leptonychotes weddellii Weddell seal XP_006739055.1 96.6 98.3 5.13E-130
Condylura cristata Star-nosed mole XP_004692437.1 91.0 95.5 3.01E-123
Orcinus orca Killer whale XP_004286877.2 88.1 92.3 1.05E-90
Trichechus manatus latirostris Florida manatee XP_004368376.1 96.6 98.9 9.95E-131
Alligator mississippiensis American alligator XP_014457972.1 69.3 88.6 1.40E-48
Chrysemys picta bellii Painted turtle XP_005307285.1 58.3 75 2.18E-78
Gekko japonicus Schlegel's Japanese gecko XP_015261231.1 56.5 72.3 4.39E-74
Thamnophis sirtalis Common garter snake XP_013914711.1 55.9 69.5 2.75E-69
Xenopus laevis African clawed frog NP_001088778.1 55.4 71.2 1.98E-68
Xenopus tropicalis Western clawed frog NP_001090717.1 52 71.2 3.57E-65
Callorhinchus milii Australian ghostshark XP_007888744.1 39.9 56.8 5.67E-43

Paralogs

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FANCD2OS has no known paralogs in Homo sapiens.

References

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[6] [5] [11] [7] [10] [9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163705Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033963Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens". Retrieved 6 February 2016.
  6. ^ a b "FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.
  7. ^ a b "AceView C3orf24". NCBI. Retrieved 2 May 2016.
  8. ^ "Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.
  9. ^ a b "NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.
  10. ^ a b "Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.
  11. ^ a b "Homologene: FANCD2OS". Retrieved 6 February 2016.