FASTKD3

FASTKD3
Identifiers
Aliases	FASTKD3, FAST kinase domains 3
External IDs	OMIM: 617530; MGI: 1916827; HomoloGene: 11457; GeneCards: FASTKD3; OMA:FASTKD3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	7,869,037 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	68,740,457 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; jejunal mucosa; ; olfactory zone of nasal mucosa; ; right uterine tube; ; kidney tubule; ; mucosa of colon; ; biceps brachii; ; hair follicle;
	Top expressed in
	zygote; ; otic vesicle; ; secondary oocyte; ; primitive streak; ; facial motor nucleus; ; primary oocyte; ; hand; ; Paneth cell; ; epiblast; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; protein binding; RNA binding;
Cellular component	mitochondrion; nucleus;
Biological process	protein phosphorylation; cellular respiration; mitochondrial cytochrome c oxidase assembly; regulation of mitochondrial mRNA stability; positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
Orthologs
	79072
	69577
	ENSG00000124279
	ENSMUSG00000021532
	Q14CZ7
	Q8BSN9
	NM_024091
	NM_027123; NM_001330423
	NP_076996
	NP_001317352; NP_081399
	Wikidata
View/Edit Human	View/Edit Mouse

FAST kinase domain-containing protein 3 (FASTKD3) is a protein that in humans is encoded by the FASTKD3 gene on chromosome 5.^[5]^[6] This protein is part of the Fas-activated serine/threonine kinase domain (FASTKD) containing protein family, which is known for regulating the energy balance of mitochondria under stress.^[7]^[8]

Structure

FASTKD3 shares structural characteristics of the FASTKD family, including an N-terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and a RNA-binding domain (RAP).^[7]^[8] The mitochondrial targeting domain directs FASTKD3 to be imported into the mitochondria. Though the functions of the C-terminal domains are unknown, RAP possibly binds RNA during trans-splicing.^[7]

Function

As a member of the FASTKD family, FASTKD3 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD3 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. FASTKD3 has been proposed to regulate energy production by serving as a scaffold protein that brings together RNA processing/translation and respiratory components.^[7]

Clinical Significance

Currently, FASTKD3 has not been linked to any disease. (Dated: September 17, 2015)

Interactions

FASTKD3 has been shown to interact with:

FASTKD2;
Fatty acid beta oxidation pathway proteins (ACADVL, ECHS1, HADHA, HADHB, ACAA2);
Amino acid catabolic pathways proteins (MCCC1, MCCC2, GLUD1, HIBADH, CPS1);
Amino acid biosynthesis proteins (PYCR1, PYCR2, ALDH18A1, SHMT2, GLS);
TCA cycle proteins (IDH3A, IDH2, SUCLG2, DLST);
Respiratory chain proteins (NDUFS1, SDHA, ATP5A1, ETFA, ETFB);
Mitochondrial RNA processing proteins (LRPPRC, DHX30, PNPT1); and
Mitochondrial translation proteins (TUFM, GFM1, IARS2, MRPS22, TARS2, MRPS2, PTCD1, MTO1, MRPS31).^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124279 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021532 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ UniProt: Q9NYY8
^ "Entrez Gene: FAST kinase domains 2".
^ ^a ^b ^c ^d ^e Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690. PMID 20869947.
^ ^a ^b Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH (Jun 2011). "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2". Molecular and Cellular Biology. 31 (11): 2287–98. doi:10.1128/MCB.01381-10. PMC 3133243. PMID 21444724.