Fetuin-B

Fetuin-B is a protein that in humans is encoded by the FETUB gene.

FETUB
Identifiers
Aliases	FETUB, 16G2, Gugu, IRL685, fetuin B
External IDs	OMIM: 605954; MGI: 1890221; HomoloGene: 8660; GeneCards: FETUB; OMA:FETUB - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.3 Start 186,635,969 bp End 186,653,141 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B1|16 13.76 cM Start 22,737,084 bp End 22,758,528 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle skin of abdomen skin of leg oral cavity mucosa of pharynx human penis vagina rectum metanephros Top expressed in olfactory epithelium esophagus left lobe of liver zygote lip secondary oocyte primary oocyte membranous bone molar Dermatocranium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity metalloendopeptidase inhibitor activity molecular function Cellular component extracellular region extracellular exosome extracellular space Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity single fertilization binding of sperm to zona pellucida biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26998 59083 Ensembl ENSG00000090512 ENSMUSG00000022871 UniProt Q9UGM5 Q9QXC1 RefSeq (mRNA) NM_001308077 NM_001308079 NM_014375 NM_001375587 NM_001375588 NM_001375589 NM_001375590 NM_001375591 NM_001375592 NM_001083904 NM_001083905 NM_021564 RefSeq (protein) NP_001295006 NP_001295008 NP_055190 NP_001362516 NP_001362517 NP_001362518 NP_001362519 NP_001362520 NP_001362521 NP_001077373 NP_001077374 NP_067539 Location (UCSC) Chr 3: 186.64 – 186.65 Mb Chr 16: 22.74 – 22.76 Mb PubMed search
Wikidata
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The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.

See also

• Fetuin-A (alpha-2-HS-glycoprotein)

Further reading

• Haidar M, Seddiki N, Gluckman JC, Gattegno L (1993). "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315–23. doi:10.1007/BF00731092. PMID 1284814. S2CID 7976435.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Denecke B, Gräber S, Schäfer C, et al. (2003). "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A". Biochem. J. 376 (Pt 1): 135–45. doi:10.1042/BJ20030676. PMC 1223762. PMID 12943536.
• Wajih N, Borras T, Xue W, et al. (2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin". J. Biol. Chem. 279 (41): 43052–60. doi:10.1074/jbc.M407180200. PMID 15280384.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hsu SJ, Nagase H, Balmain A (2005). "Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity". Genome. 47 (5): 931–46. doi:10.1139/g04-043. PMID 15499407.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Coen G, Ballanti P, Balducci A, et al. (2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry". Am. J. Kidney Dis. 48 (1): 106–13. doi:10.1053/j.ajkd.2006.03.083. PMID 16797392.