Filamin A interacting protein 1 like

Filamin A interacting protein 1 like is a protein that in humans is encoded by the FILIP1L gene.

FILIP1L
Identifiers
Aliases	FILIP1L, DOC-1, DOC1, GIP130, GIP90, filamin A interacting protein 1-like, filamin A interacting protein 1 like
External IDs	OMIM: 612993; MGI: 1925999; HomoloGene: 37121; GeneCards: FILIP1L; OMA:FILIP1L - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q12.1 Start 99,828,811 bp End 100,114,513 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C1.1 Start 57,173,456 bp End 57,393,489 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tail of epididymis vena cava urethra Descending thoracic aorta superficial temporal artery ascending aorta right coronary artery popliteal artery tibial arteries Top expressed in ascending aorta genital tubercle external carotid artery hand carotid body aortic valve umbilical cord lymph node spleen internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component cytoplasm membrane nucleus Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11259 78749 Ensembl ENSG00000168386 ENSMUSG00000043336 UniProt Q4L180 Q6P6L0 RefSeq (mRNA) NM_001042459 NM_001282793 NM_001282794 NM_014890 NM_182909 NM_001370247 NM_001387850 NM_001387851 NM_001387852 NM_001040397 NM_001177871 RefSeq (protein) NP_001035924 NP_001269722 NP_001269723 NP_055705 NP_878913 NP_001357176 NP_001035487 NP_001171342 Location (UCSC) Chr 3: 99.83 – 100.11 Mb Chr 16: 57.17 – 57.39 Mb PubMed search
Wikidata
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Further reading

• Tandle AT, Mazzanti C, Alexander HR, Roberts DD, Libutti SK (2005). "Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells". Cytokine. 30 (6): 347–58. doi:10.1016/j.cyto.2005.01.020. PMID 15935955.
• Quaye L, Dafou D, Ramus SJ, Song H, Gentry-Maharaj A, Maharaj AG, Notaridou M, Hogdall E, Kjaer SK, Christensen L, Hogdall C, Easton DF, Jacobs I, Menon U, Pharoah PD, Gayther SA (2009). "Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival". Hum. Mol. Genet. 18 (10): 1869–78. doi:10.1093/hmg/ddp107. PMID 19270026.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ (2011). "Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer". Int. J. Cancer. 128 (9): 2063–74. doi:10.1002/ijc.25554. PMC 3098608. PMID 20635389.
• Burton ER, Gaffar A, Lee SJ, Adeshuko F, Whitney KD, Chung JY, Hewitt SM, Huang GS, Goldberg GL, Libutti SK, Kwon M (2011). "Downregulation of Filamin A interacting protein 1-like is associated with promoter methylation and induces an invasive phenotype in ovarian cancer". Mol. Cancer Res. 9 (8): 1126–38. doi:10.1158/1541-7786.MCR-11-0162. PMC 3157597. PMID 21693594.
• Hu Y, Mivechi NF (2011). "Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L)". J. Biol. Chem. 286 (36): 31397–408. doi:10.1074/jbc.M111.255851. PMC 3173115. PMID 21784850.
• Revert-Ros F, López-Pascual E, Granero-Moltó F, Macías J, Breyer R, Zent R, Hudson BG, Saadeddin A, Revert F, Blasco R, Navarro C, Burks D, Saus J (2011). "Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130)". J. Biol. Chem. 286 (40): 35030–43. doi:10.1074/jbc.M111.249458. PMC 3186396. PMID 21832087.
• Beaty TH, Taub MA, Scott AF, Murray JC, Marazita ML, Schwender H, Parker MM, Hetmanski JB, Balakrishnan P, Mansilla MA, Mangold E, Ludwig KU, Noethen MM, Rubini M, Elcioglu N, Ruczinski I (2013). "Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study". Hum. Genet. 132 (7): 771–81. doi:10.1007/s00439-013-1283-6. PMC 3707506. PMID 23512105.
• Kwon M, Lee SJ, Wang Y, Rybak Y, Luna A, Reddy S, Adem A, Beaty BT, Condeelis JS, Libutti SK (2014). "Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis". Int. J. Cancer. 135 (1): 48–60. doi:10.1002/ijc.28662. PMC 3991758. PMID 24327474.