GTF2E1

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.

GTF2E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VD4, 2JTX, 2RNQ, 2RNR, 5IY9, 5IYC, 5IYD, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8
Identifiers
Aliases	GTF2E1, FE, TF2E1, TFIIE-A, general transcription factor IIE subunit 1
External IDs	OMIM: 189962; MGI: 1921447; HomoloGene: 38062; GeneCards: GTF2E1; OMA:GTF2E1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.33 Start 120,742,637 bp End 120,783,069 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 37,330,152 bp End 37,360,151 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle gonad periodontal fiber sperm monocyte stromal cell of endometrium right adrenal cortex islet of Langerhans Top expressed in hand superior cervical ganglion otic vesicle endocardial cushion primitive streak medial ganglionic eminence abdominal wall atrioventricular valve iris trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding sequence-specific DNA binding protein binding RNA polymerase II complex binding TFIIH-class transcription factor complex binding RNA polymerase II general transcription initiation factor activity Cellular component nucleus nucleoplasm transcription factor TFIID complex cytosol transcription preinitiation complex transcription factor TFIIE complex Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II viral process transcription open complex formation at RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2960 74197 Ensembl ENSG00000153767 ENSMUSG00000022828 UniProt P29083 Q9D0D5 RefSeq (mRNA) NM_005513 NM_028812 NM_001355727 RefSeq (protein) NP_005504 NP_083088 NP_001342656 Location (UCSC) Chr 3: 120.74 – 120.78 Mb Chr 16: 37.33 – 37.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Transcription factor II E

Further reading

• Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B (July 2007). "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme". Molecular Cell. 27 (2): 262–74. doi:10.1016/j.molcel.2007.06.027. PMC 4498903. PMID 17643375.
• Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B (October 2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". The Journal of Biological Chemistry. 276 (42): 38652–7. doi:10.1074/jbc.M106422200. PMC 4492724. PMID 11509574.
• Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A (January 2009). "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study". Gynecologic Oncology. 112 (1): 210–4. doi:10.1016/j.ygyno.2008.09.012. PMID 18950845.
• Yamamoto S, Watanabe Y, van der Spek PJ, Watanabe T, Fujimoto H, Hanaoka F, Ohkuma Y (January 2001). "Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation". Molecular and Cellular Biology. 21 (1): 1–15. doi:10.1128/MCB.21.1.1-15.2001. PMC 86563. PMID 11113176.
• Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y (April 2003). "The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II". Molecular and Cellular Biology. 23 (8): 2914–26. doi:10.1128/mcb.23.8.2914-2926.2003. PMC 152561. PMID 12665589.
• Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A (May 2006). "Structure and oligomeric state of human transcription factor TFIIE". EMBO Reports. 7 (5): 500–5. doi:10.1038/sj.embor.7400663. PMC 1479554. PMID 16547462.
• Orphanides G, Lagrange T, Reinberg D (November 1996). "The general transcription factors of RNA polymerase II". Genes & Development. 10 (21): 2657–83. doi:10.1101/gad.10.21.2657. PMID 8946909.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
• Kim TK, Ebright RH, Reinberg D (May 2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science. 288 (5470): 1418–22. Bibcode:2000Sci...288.1418K. doi:10.1126/science.288.5470.1418. PMID 10827951.
• Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
• Yu X, Li P, Roeder RG, Wang Z (July 2001). "Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split". Molecular and Cellular Biology. 21 (14): 4614–25. doi:10.1128/MCB.21.14.4614-4625.2001. PMC 87125. PMID 11416139.
• Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG (January 2008). "p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH". Proceedings of the National Academy of Sciences of the United States of America. 105 (1): 106–11. Bibcode:2008PNAS..105..106D. doi:10.1073/pnas.0707892105. PMC 2224167. PMID 18160537.
• Liu L, Ishihara K, Ichimura T, Fujita N, Hino S, Tomita S, Watanabe S, Saitoh N, Ito T, Nakao M (February 2009). "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity". The Journal of Biological Chemistry. 284 (8): 5165–74. doi:10.1074/jbc.M807098200. PMID 19106100.
• Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (July 1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". The Journal of Biological Chemistry. 273 (31): 19866–76. doi:10.1074/jbc.273.31.19866. PMID 9677423.
• Okuda M, Tanaka A, Arai Y, Satoh M, Okamura H, Nagadoi A, Hanaoka F, Ohkuma Y, Nishimura Y (December 2004). "A novel zinc finger structure in the large subunit of human general transcription factor TFIIE". The Journal of Biological Chemistry. 279 (49): 51395–403. doi:10.1074/jbc.M404722200. PMID 15385556.
• Okuda M, Tanaka A, Satoh M, Mizuta S, Takazawa M, Ohkuma Y, Nishimura Y (April 2008). "Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH". The EMBO Journal. 27 (7): 1161–71. doi:10.1038/emboj.2008.47. PMC 2275666. PMID 18354501.
• Fraser RA, Heard DJ, Adam S, Lavigne AC, Le Douarin B, Tora L, Losson R, Rochette-Egly C, Chambon P (June 1998). "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". The Journal of Biological Chemistry. 273 (26): 16199–204. doi:10.1074/jbc.273.26.16199. PMID 9632676.
• Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y (March 2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.