3-hydroxyacyl-CoA dehydratase 2

3-hydroxyacyl-CoA dehydratase 2 is a protein that in humans is encoded by the HACD2 gene.

HACD2
Identifiers
Aliases	HACD2, PTPLB, 3-hydroxyacyl-CoA dehydratase 2
External IDs	OMIM: 615939; MGI: 1918007; HomoloGene: 23409; GeneCards: HACD2; OMA:HACD2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.1 Start 123,490,820 bp End 123,585,053 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 34,842,798 bp End 34,929,547 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium external globus pallidus vulva jejunal mucosa skin of thigh skin of hip endothelial cell mucosa of colon mucosa of sigmoid colon human penis Top expressed in right kidney tail of embryo lip yolk sac genital tubercle zygote esophagus granulocyte embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity enzyme binding 3-hydroxyacyl-CoA dehydratase activity protein binding lyase activity 3R-hydroxyacyl-CoA dehydratase activity 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity 3-hydroxy-arachidoyl-CoA dehydratase activity very-long-chain 3-hydroxyacyl-CoA dehydratase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of endoplasmic reticulum membrane Biological process fatty acid elongation fatty acid biosynthetic process sphingolipid biosynthetic process long-chain fatty-acyl-CoA biosynthetic process very long-chain fatty acid biosynthetic process fatty acid metabolic process lipid metabolism peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 201562 70757 Ensembl ENSG00000206527 ENSMUSG00000035376 UniProt Q6Y1H2 Q9D3B1 RefSeq (mRNA) NM_001329783 NM_001329784 NM_001329786 NM_001329787 NM_198402 NM_023587 RefSeq (protein) NP_001316712 NP_001316713 NP_001316715 NP_001316716 NP_940684 NP_076076 Location (UCSC) Chr 3: 123.49 – 123.59 Mb Chr 16: 34.84 – 34.93 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane.

Further reading

• Wang B, Pelletier J, Massaad MJ, Herscovics A, Shore GC (2004). "The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B". Mol. Cell. Biol. 24 (7): 2767–78. doi:10.1128/mcb.24.7.2767-2778.2004. PMC 371098. PMID 15024066.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.