HACL1 (gene)

2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene.

HACL1
Identifiers
Aliases	HACL1, 2-HPCL, HPCL, HPCL2, PHYH2, 2-hydroxyacyl-CoA lyase 1
External IDs	OMIM: 604300; MGI: 1929657; HomoloGene: 5794; GeneCards: HACL1; OMA:HACL1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.1 Start 15,560,699 bp End 15,601,852 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 B Start 31,320,687 bp End 31,363,243 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum right lobe of liver secondary oocyte gonad skin of arm mucosa of ileum testicle right testis skin of thigh Top expressed in liver lip renal cortex spermatocyte proximal tubule human kidney right kidney white adipose tissue vasculature of organ bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function thiamine pyrophosphate binding signaling receptor binding protein binding catalytic activity magnesium ion binding metal ion binding lyase activity carbon-carbon lyase activity identical protein binding Cellular component peroxisome peroxisomal matrix cytosol Biological process fatty acid alpha-oxidation protein complex oligomerization fatty acid metabolic process protein targeting to peroxisome lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26061 56794 Ensembl ENSG00000131373 ENSMUSG00000021884 UniProt Q9UJ83 Q9QXE0 RefSeq (mRNA) NM_001284413 NM_001284415 NM_001284416 NM_012260 NM_019975 RefSeq (protein) NP_001271342 NP_001271344 NP_001271345 NP_036392 NP_064359 Location (UCSC) Chr 3: 15.56 – 15.6 Mb Chr 14: 31.32 – 31.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.