Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene.[5] HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.

HAPLN2
Identifiers
AliasesHAPLN2, BRAL1, hyaluronan and proteoglycan link protein 2
External IDsMGI: 2137300; HomoloGene: 11045; GeneCards: HAPLN2; OMA:HAPLN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021817

NM_022031

RefSeq (protein)

NP_068589

NP_071314

Location (UCSC)Chr 1: 156.62 – 156.63 MbChr 3: 87.93 – 87.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132702Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004894Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: hyaluronan and proteoglycan link protein 2".
  6. ^ Bekku Y, Vargová L, Goto Y, Vorísek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fässler R, Ninomiya Y, Syková E, Oohashi T (Feb 2010). "Bral1: its role in diffusion barrier formation and conduction velocity in the CNS". The Journal of Neuroscience. 30 (8): 3113–23. doi:10.1523/JNEUROSCI.5598-09.2010. PMC 6633924. PMID 20181608.

Further reading

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