major histocompatibility complex (human), class I, B18
Alleles B*1801
Alleles B*1802
Alleles B*1803
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*1801
EBI-HLA B*1802
EBI-HLA B*1803
Locus chr.6 6p21.31

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

Serotype

edit

B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01.[2]

B18 serotype recognition of Some HLA B*18 allele-group gene products[3]
B*18 B18 Sample
allele % % size (N)
1801 96 1641
1802 90 31
1803 83 29

Allele frequencies

edit
HLA B*1801 frequencies
freq
ref. Population (%)
[4] Italy North pop 1 16.7
[4] Croatia 11.3
[4] Georgia Svaneti Svans 11.3
[4] Romanian 11.3
[4] Portugal South 11.2
[4] Singapore Riau Malay 9.9
[4] Bulgaria 9.1
[4] Israel Arab Druse 8.5
[4] Azores Central Islands 8.0
[4] Portugal Centre 8.0
[4] Finland 7.8
[4] Azores Santa Maria and Sao Miguel 7.7
[4] Czech Republic 7.5
[4] India Jalpaiguri Toto 7.5
[4] Iran Baloch 7.1
[4] Philippines Ivatan 7.0
[4] Thailand 6.7
[4] Tunisia 6.7
[4] Portugal North 6.5
[4] Zimbabwe Harare Shona 6.4
[4] Madeira 6.2
[4] Mexico Mestizos 6.1
[4] Kenya 5.9
[4] Belgium 5.1
[4] Morocco Nador Metalsa Class I 5.1
[4] Singapore Javanese Indonesians 5.1
[4] Israel Ashkenazi and Non Ashkenazi Jews 5.0
[4] Uganda Kampala 5.0
[4] Kenya Nandi 4.8
[4] Oman 4.7
[4] Georgia Tbilisi Georgians 4.6
[4] Bulgaria Gipsy 4.5
[4] France South East 4.3
[4] Kenya Luo 4.3
[4] Ireland South 4.2
[4] Russia Arkhangelsk Pomors 4.0
[4] Azores Terceira Island 3.9
[4] Guinea Bissau 3.8
[4] India New Delhi 3.8
[4] Spain Eastern Andalusia Gipsy 3.5
[4] Australia New South Wales 3.4
[4] Georgia Tbilisi Kurds 3.4
[4] Zambia Lusaka 3.4
[4] Cameroon Yaounde 2.7
[4] Senegal Niokholo Mandenka 2.7
[4] Cameroon Beti 2.3
[4] Ivory Coast Akan Adiopodoume 2.3
[4] Sudanese 2.3
[4] Saudi Arabia Guraiat and Hail 2.2
[4] South African Natal Zulu 2.0
[4] Thailand 2.0
[4] India Mumbai Marathas 1.9
[4] New Caledonia 1.9
[4] Papua New Guinea Wanigela 1.5
[4] Cameroon Bamileke 1.3

References

edit
  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.