| |
major histocompatibility complex, class II, DR13
| |
| Haplotypes groups | DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 .... |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1301 to *1308 *1310
|
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1301 |
| EBI-HLA | DRB1*1302 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1304 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1306 |
| EBI-HLA | DRB1*1307 Archived 2007-09-26 at the Wayback Machine |
| EBI-HLA | DRB1*1310 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.
Alleles
edit| DRB1* | DR13 | DR6 | DR14 | Sample |
| allele | % | % | % | size (N) |
| 1301 | 81 | 14 | 1 | 3788 |
| 1302 | 74 | 17 | 2 | 3081 |
| 1303 | 69 | 10 | 2 | 948[2] |
| 1304 | 87 | 127 | ||
| 1305 | 54 | 12 | 305[3] | |
| 1306 | 78 | 9 | ||
| 1307 | >50 | 1 | ||
| 1308 | 45 | 55 | 9 | |
| 1310 | >75 | 5 |
Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379 DRB1*13 allele group
- 81 Alleles: 74 proteins
- DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
- DR6 (weak DR13) Serotype: *1308
- DR13&Other serotypes: *1303, *1305, *1311,
- Serotype unknown: *1309, *1315 to *1374
Disease associations
editDRB1*1302 is linked to early childhood myastenia gravis.[4] Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.
Extended linkage
editDRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis[4]
Genetic Linkage
editDR13 Haplotypes
| |||
| DRA | DRB1 | DRB3 | |
|---|---|---|---|
| DR13(6)-DR52 | *0101 | *1301 | *0101 |
| *0101 | *1301 | *0201 | |
| *0101 | *1302 | *0301 | |
| DQA1 | DQB1 | DRB1 | |
| DR13(6)-DQ6(6.3, 1) | *0103 | *0603 | *1301 |
| DR13(6)-DQ6(6.4, 1) | *0102 | *0604 | *1302 |
| DR13(6)-DQ6(6.5, 1) | *0102 | *0605 | *1302 |
| DR13(6)-DQ6(6.9, 1) | *0102 | *0609 | *1302 |
| HLA-A | HLA-B | DRB1 | |
| A2-Cw5-B44(16)-DR13 | *02 | *4402 | *1301 |
HLA-DR13 is genetically linked to DR52[5] and HLA-DQ6 (HLA-DQ1) serotypes.
References
edit- ^ derived from IMGT/HLA
- ^ DR12 - 3%, DR11 - 3% DR5-2%
- ^ DR12 - 6%, DR11 - 7% DR5-4%
- ^ a b Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812.
- ^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.