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major histocompatibility complex, class II, DR14
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| Haplotypes groups | DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
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| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1401 to *1408 *1410
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| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1401 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1402 |
| EBI-HLA | DRB1*1403 |
| EBI-HLA | DRB1*1404 |
| EBI-HLA | DRB1*1405 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1406 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.
Alleles
edit| DRB1* | DR14 | DR6 | DR13 | Sample |
| allele | % | % | % | size (N) |
| 1401 | 74 | 14 | 3 | 1942 |
| 1402 | 61 | 13 | 9 | 204 |
| 1403 | 72 | 12 | 2 | 37 |
| 1404 | 79 | 8 | 80[2] | |
| 1405 | 86 | 10 | 58 | |
| 1406 | 37 | 15 | 22 | 117 |
| 1407 | 90 | 10 | ||
| 1408 | 25 | 4 | ||
| 1410 | >75 | 4 |
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
Disease associations
editDRB1*1402: juvenile rheumatoid arthritis,[4] increased longevity in Okinawans.
Extended linkage
editDR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.[5]
Genetic Linkage
editDR14 Haplotypes
| |||
| DRA | DRB1 | DRB3 | |
|---|---|---|---|
| DR14(6)-DR52 | *0101 | *1401 | *0201 |
| *0101 | *1402 | *0201 | |
| *0101 | *1403 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR14-DQ5(5.3, 1) | *0104 | *0503 | *1401 |
| HLA-A | HLA-B | DRB1 | |
| A11-B35-DR14(6) | *1101 | *3501 | *1401 |
| A2-B51(5)-DR14(6) | *0201 | *5101 | *1401 |
HLA-DR13 is genetically linked to HLA-DR52[6] and HLA-DQ5 (HLA-DQ1) serotypes.
References
edit- ^ derived from IMGT/HLA
- ^ DR1404 - 3%
- ^ DR4 - 25%
- ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
- ^ Niks EH, Kuks JB, Roep BO, et al. (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology. 66 (11): 1772–4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963. S2CID 41206495.
- ^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.