HMCES

HMCES
Identifiers
Aliases	HMCES, C3orf37, SRAPD1, DC12, 5-hydroxymethylcytosine (hmC) binding, ES cell-specific, 5-hydroxymethylcytosine binding, ES cell specific
External IDs	OMIM: 618288; MGI: 1914053; HomoloGene: 6636; GeneCards: HMCES; OMA:HMCES - orthologs
EC number	3.4.-.-
Gene location (Human)
Chr.	Chromosome 3 (human)
End	129,306,186 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,913,611 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gastrocnemius muscle; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; muscle of thigh; ; lymph node; ; apex of heart; ; secondary oocyte; ; left testis;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; embryo; ; tail of embryo; ; yolk sac; ; ventricular zone; ; granulocyte; ; genital tubercle; ; right kidney;
	More reference expression data
	n/a
Orthologs
	56941
	232210
	ENSG00000183624
	ENSMUSG00000030060
	Q96FZ2
	Q8R1M0
NM_001006109; NM_020187; NM_001363881; NM_001370343; NM_001370344;
	NM_001370345
	NM_173737
NP_001006109; NP_064572; NP_001350810; NP_001357272; NP_001357273;
	NP_001357274
	NP_776098
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxymethylcytosine binding, ES cell specific is a protein that in humans is encoded by the HMCES gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183624 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030060 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: 5-hydroxymethylcytosine binding, ES cell specific". Retrieved 2018-05-16.

Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M (June 2014). "Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain". Neurobiol. Aging. 35 (6): 1334–44. doi:10.1016/j.neurobiolaging.2013.11.031. PMID 24387984. S2CID 25277574.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K (August 2014). "Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain". Neurobiol. Aging. 35 (8): 1850–4. doi:10.1016/j.neurobiolaging.2014.02.002. PMC 4066184. PMID 24679604.
Kraus TF, Guibourt V, Kretzschmar HA (July 2015). "5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing". J Neural Transm (Vienna). 122 (7): 1035–43. doi:10.1007/s00702-014-1346-4. PMID 25471351. S2CID 34905929.
Zhang LY, Li PL, Wang TZ, Zhang XC (October 2015). "Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer". Arch. Gynecol. Obstet. 292 (4): 891–7. doi:10.1007/s00404-015-3704-3. PMID 25827305. S2CID 24483457.
Biayna, Josep; Garcia-Cao, Isabel; Álvarez, Miguel M.; Salvadores, Marina; Espinosa-Carrasco, Jose; McCullough, Marcel; Supek, Fran; Stracker, Travis H. (2021-03-31). "Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells". PLOS Biology. 19 (3): e3001176. doi:10.1371/journal.pbio.3001176. PMC 8041192. PMID 33788831.</ref>

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