Horiuchi (written: 堀内) is a Japanese surname. Notable people with the surname include:
- Annick Horiuchi, French historian of mathematics
- Gen Horiuchi (堀内 元), Japanese ballet dancer and choreographer
- Glenn Horiuchi (1955–2000), American jazz pianist, composer, and shamisen player
- Hatsutarō Horiuchi (堀内 初太郎, 1909–1986), Japanese photographer
- Iwao Horiuchi (堀内 岩雄, born 1941), Japanese sport wrestler
- Ken Horiuchi (堀内 健, born 1969), Japanese comedian
- Kenyu Horiuchi (堀内 賢雄, born 1957), Japanese voice actor
- Lon Horiuchi (born 1954), American FBI sniper
- Masami Horiuchi (堀内 正美, born 1950), Japanese actor
- Mika Horiuchi (born 1986), American musician
- Mitsuo Horiuchi (堀内 光雄, born 1930), Japanese politician
- Noriko Horiuchi (ほりうち のりこ, born 1965), Japanese politician
- Paul Horiuchi (1906–1999), Japanese-American painter and collagist
- Shunsuke Horiuchi (堀内 俊介, born 1959), Japanese rower
- Takao Horiuchi (堀内 孝雄, born 1949), Japanese pop and enka singer
- Terufumi Horiuchi (堀内 照文), Japanese politician
- Toyoaki Horiuchi (堀内 豊秋, 1900–1948), Imperial Japanese Navy officer
- Tsuneo Horiuchi (堀内 恒夫, born 1948), Japanese baseball player
- Yu Horiuchi (堀内 優, born 1990), Japanese sport wrestler