IHPK2

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.

IP6K2
Identifiers
Aliases	IP6K2, IHPK2, PIUS, inositol hexakisphosphate kinase 2, InsP6K2
External IDs	OMIM: 606992; MGI: 1923750; HomoloGene: 56929; GeneCards: IP6K2; OMA:IP6K2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 48,688,003 bp End 48,740,353 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum ganglionic eminence tibial nerve skin of abdomen skin of leg right uterine tube mucosa of transverse colon body of uterus anterior pituitary left ovary n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding protein binding ATP binding inositol hexakisphosphate 3-kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol 5-diphosphate pentakisphosphate 5-kinase activity inositol diphosphate tetrakisphosphate kinase activity inositol heptakisphosphate kinase activity inositol hexakisphosphate kinase activity flavonoid binding Cellular component nucleus nucleoplasm fibrillar center cell junction intermediate filament cytoskeleton Biological process phosphate ion transport phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process type I interferon signaling pathway negative regulation of cell growth phosphorylation positive regulation of apoptotic process inositol phosphate biosynthetic process cellular response to flavonoid lipid metabolism phosphatidylinositol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51447 76500 Ensembl ENSG00000068745 ENSMUSG00000032599 UniProt Q9UHH9 Q80V72 RefSeq (mRNA) NM_001005909 NM_001005910 NM_001005911 NM_001005912 NM_001005913 NM_001146178 NM_001146179 NM_001190316 NM_001190317 NM_016291 NM_029634 RefSeq (protein) NP_001005909 NP_001005910 NP_001005911 NP_001139650 NP_001139651 NP_001177245 NP_001177246 NP_057375 NP_083910 NP_001366529 NP_001366530 NP_001366531 NP_001366532 Location (UCSC) Chr 3: 48.69 – 48.74 Mb n/a PubMed search
Wikidata
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This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID 9776982. S2CID 22338269.
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
• Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ (2001). "Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells". J. Biol. Chem. 276 (27): 24965–70. doi:10.1074/jbc.M101161200. PMC 2025680. PMID 11337497.
• Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
• Morrison BH, Bauer JA, Hu J, et al. (2002). "Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics". Oncogene. 21 (12): 1882–9. doi:10.1038/sj.onc.1205265. PMC 2043497. PMID 11896621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nagata E, Luo HR, Saiardi A, et al. (2005). "Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death". J. Biol. Chem. 280 (2): 1634–40. doi:10.1074/jbc.M409416200. PMID 15533939.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Morrison BH, Bauer JA, Lupica JA, et al. (2007). "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation". J. Biol. Chem. 282 (21): 15349–56. doi:10.1074/jbc.M700156200. PMC 2048714. PMID 17379600.

See also

• Inositol-hexakisphosphate kinase