Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a cytokine receptor . This receptor specifically binds to IL17B and IL17E (IL25) , but does not bind to IL17(A) or IL17C . This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation , which suggested the immunoregulatory activity of this receptor.[ 7]
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