Interferon lambda receptor 1

IFNLR1
Identifiers
Aliases	IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2, Interleukin 28 receptor, alpha subunit, interferon lambda receptor 1
External IDs	OMIM: 607404; MGI: 2429859; GeneCards: IFNLR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OG4, 3OG6, 5IXI, 5IXD
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,187,959 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,435,492 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; buccal mucosa cell; ; right lobe of liver; ; testicle; ; mucosa of sigmoid colon; ; cerebellar vermis; ; duodenum; ; cerebellar hemisphere; ; lymph node;
	Top expressed in
	granulocyte; ; urethra; ; jejunum; ; transitional epithelium of urinary bladder; ; middle ear; ; lip; ; ileum; ; duodenum; ; esophagus; ; Hindgut;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine receptor activity; protein binding;
Cellular component	integral component of membrane; interleukin-28 receptor complex; membrane; plasma membrane;
Biological process	response to type III interferon; mucosal immune response; defense response to virus; negative regulation of cell population proliferation; regulation of defense response to virus by host; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	163702
	242700
	ENSG00000185436
	ENSMUSG00000062157
	Q8IU57
	Q8CGK5
	NM_170743; NM_173064; NM_173065
	NM_174851
	NP_734464; NP_775087; NP_775088
	NP_777276
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon lambda receptor 1 is a subunit for the interferon lambda receptor encoded by the IFNLR1 gene. It was formerly known as interleukin 28 receptor, alpha subunit. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with interferon type III (IL28A, IL28B, IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185436 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062157 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185436 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062157 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".

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