A Link domain or Link module, also known as Xlink domain (X for extracellular), is a protein domain that binds to hyaluronic acid.[1] It is important in blood cell migration and apoptosis.[2] The link domain is found in some extracellular proteins in vertebrates such as the hyalectans.[3] It appears to be involved in extracellular matrix assembly and stability, cell adhesion, and migration.[3][4]

Link domain
Structure of the hyaluronan-binding domain of human CD44
Identifiers
SymbolLINK
PfamPF00193
Pfam clanCL0056
InterProIPR000538
SMARTSM00445
PROSITEPDOC00955
SCOP21o7b / SCOPe / SUPFAM
CDDcd01102
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Structure

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The structure has been shown to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core similar to that of C-type lectin.[5] This domain contains four conserved cysteines involved in two disulphide bonds. The link domain has also been termed HABM (hyaluronic acid binding module)[4] and PTR (proteoglycan tandem repeat).[6]

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Proteins which contain the link domain include:

See also

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References

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  1. ^ "Link domain signature and profile". PROSITE. December 2004. Retrieved 30 September 2016.
  2. ^ Yoneda M, Nakamura T, Murai M, Wada H (2010). "Evidence for the heparin-binding ability of the ascidian Xlink domain and insight into the evolution of the Xlink domain in chordates". J Mol Evol. 71 (1): 51–9. Bibcode:2010JMolE..71...51Y. doi:10.1007/s00239-010-9363-x. PMID 20582409. S2CID 10614265.
  3. ^ a b Hynes, RO; Naba, A (21 September 2011). "Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions". Cold Spring Harbor Perspectives in Biology. 4 (1): a004903. doi:10.1101/cshperspect.a004903. PMC 3249625. PMID 21937732.
  4. ^ a b Barta E, Deák F, Kiss I (June 1993). "Evolution of the hyaluronan-binding module of link protein". Biochem. J. 292 (3): 947–9. doi:10.1042/bj2920947. PMC 1134205. PMID 8318021.
  5. ^ Kohda D, Morton CJ, Parkar AA, Hatanaka H, Inagaki FM, Campbell ID, Day AJ (September 1996). "Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration". Cell. 86 (5): 767–75. doi:10.1016/S0092-8674(00)80151-8. PMID 8797823. S2CID 16347386.
  6. ^ Brissett NC, Perkins SJ (June 1996). "The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily". FEBS Lett. 388 (2–3): 211–6. doi:10.1016/0014-5793(96)00576-5. PMID 8690089. S2CID 24295651.
This article incorporates text from the public domain Pfam and InterPro: IPR000538