MED12L

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene.

MED12L
Identifiers
Aliases	MED12L, NOPAR, TNRC11L, TRALP, TRALPUSH, mediator complex subunit 12 like, mediator complex subunit 12L, NIZIDS
External IDs	OMIM: 611318; MGI: 2139916; HomoloGene: 43143; GeneCards: MED12L; OMA:MED12L - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.1 Start 151,085,286 bp End 151,437,072 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 D Start 58,913,246 bp End 59,226,103 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle secondary oocyte bone marrow cells gonad ventricular zone ganglionic eminence sural nerve prefrontal cortex Achilles tendon Top expressed in substantia nigra olfactory epithelium motor neuron renal corpuscle epithelium of lens dorsomedial hypothalamic nucleus fossa lumbar subsegment of spinal cord condyle anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity beta-catenin binding transcription coregulator activity Cellular component nucleus mediator complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116931 329650 Ensembl ENSG00000144893 ENSMUSG00000056476 UniProt Q86YW9 Q8BQM9 RefSeq (mRNA) NM_053002 NM_001393769 NM_177855 RefSeq (protein) NP_443728 NP_808523 Location (UCSC) Chr 3: 151.09 – 151.44 Mb Chr 3: 58.91 – 59.23 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010].

See also

• Mediator

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.