MIR885 (gene)

MicroRNA 885 is a protein that in humans is encoded by the MIR885 gene.

MIR885
Identifiers
Aliases	MIR885, MIRN885, hsa-mir-885, mir-885, microRNA 885
External IDs	GeneCards: MIR885; OMA:MIR885 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.3 Start 10,394,489 bp End 10,394,562 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of leg substantia nigra right lobe of liver tibial nerve Brodmann area 9 right frontal lobe putamen ascending aorta amygdala skin of leg n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100126334 n/a Ensembl ENSG00000216135 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 3: 10.39 – 10.39 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, Fischer M, Zapatka M, Brors B, Savelyeva L, Sagulenko V, Speleman F, Schwab M, Westermann F (June 2011). "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival". Cell Death Differ. 18 (6): 974–84. doi:10.1038/cdd.2010.164. PMC 3131937. PMID 21233845.
• Huang X, Xu S, Gao J, Liu F, Yue J, Chen T, Wu B (October 2011). "miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". Int. J. Mol. Med. 28 (4): 659–67. doi:10.3892/ijmm.2011.721. PMID 21687927.
• Huang Y, Chuang AY, Ratovitski EA (November 2011). "Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure". Cell Cycle. 10 (22): 3938–47. doi:10.4161/cc.10.22.18107. PMC 3266119. PMID 22071691.
• Guan X, Liu Z, Liu H, Yu H, Wang LE, Sturgis EM, Li G, Wei Q (April 2013). "A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer". FASEB J. 27 (4): 1404–12. doi:10.1096/fj.12-223420. PMC 3606531. PMID 23271051.
• Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S (March 2015). "Signature of circulating microRNAs in osteoarthritis" (PDF). Ann. Rheum. Dis. 74 (3): e18. doi:10.1136/annrheumdis-2013-204698. hdl:2318/1613106. PMID 24515954.
• Xiao F, Qiu H, Cui H, Ni X, Li J, Liao W, Lu L, Ding K (April 2015). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling". Oncogene. 34 (15): 1968–78. doi:10.1038/onc.2014.134. PMID 24882581. S2CID 11424568.
• Plieskatt JL, Rinaldi G, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM (October 2014). "Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini" (PDF). J. Hepatol. 61 (4): 850–8. doi:10.1016/j.jhep.2014.05.035. PMID 25017828.
• Hur K, Toiyama Y, Schetter AJ, Okugawa Y, Harris CC, Boland CR, Goel A (March 2015). "Identification of a metastasis-specific MicroRNA signature in human colorectal cancer". J. Natl. Cancer Inst. 107 (3). doi:10.1093/jnci/dju492. PMC 4334826. PMID 25663689.
• El-Diwany R, Wasilewski LN, Witwer KW, Bailey JR, Page K, Ray SC, Cox AL, Thomas DL, Balagopal A (September 2015). "Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release". J. Virol. 89 (18): 9454–64. doi:10.1128/JVI.00955-15. PMC 4542372. PMID 26157120.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.