Maiorana is a surname. Notable people with the surname include:
- Bruno Maïorana (born 1966), French cartoonist
- Daniel Maiorana (born c. 1977), founder of a Swedish gang
- Giuliano Maiorana (born 1969), English footballer
- Marcello Maiorana (died 1586), Roman Catholic prelate
- Mark Maiorana (born 1956), American politician