MicroRNA 138-1

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MIR138-1
Identifiers
Aliases	MIR138-1, MIRN138-1, mir-138-1, microRNA 138-1
External IDs	OMIM: 613394; GeneCards: MIR138-1; OMA:MIR138-1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.32 Start 44,114,212 bp End 44,114,310 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle blood upper lobe of left lung intestine monocyte corpus callosum left adrenal gland left lobe of thyroid gland amygdala human kidney n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406929 n/a Ensembl ENSG00000207954 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 3: 44.11 – 44.11 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Further reading

• Liu X, Jiang L, Wang A, Yu J, Shi F, Zhou X (2009). "MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines". Cancer Lett. 286 (2): 217–22. doi:10.1016/j.canlet.2009.05.030. PMC 2783372. PMID 19540661.
• Jiang L, Dai Y, Liu X, Wang C, Wang A, Chen Z, Heidbreder CE, Kolokythas A, Zhou X (2011). "Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma". Hum. Genet. 129 (2): 189–97. doi:10.1007/s00439-010-0915-3. PMC 3121246. PMID 21079996.
• Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, Kassem M (2011). "MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo". Proc. Natl. Acad. Sci. U.S.A. 108 (15): 6139–44. Bibcode:2011PNAS..108.6139E. doi:10.1073/pnas.1016758108. PMC 3076836. PMID 21444814.
• Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T (2011). "MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression". Mol. Cancer Res. 9 (8): 1100–11. doi:10.1158/1541-7786.MCR-11-0007. PMC 3157593. PMID 21693595.
• Song T, Zhang X, Wang C, Wu Y, Cai W, Gao J, Hong B (2011). "MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells". Asian Pac. J. Cancer Prev. 12 (5): 1307–11. PMID 21875287.
• Liu X, Lv XB, Wang XP, Sang Y, Xu S, Hu K, Wu M, Liang Y, Liu P, Tang J, Lu WH, Feng QS, Chen LZ, Qian CN, Bei JX, Kang T, Zeng YX (2012). "MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene". Cell Cycle. 11 (13): 2495–506. doi:10.4161/cc.20898. PMID 22739938.
• Yamasaki T, Seki N, Yamada Y, Yoshino H, Hidaka H, Chiyomaru T, Nohata N, Kinoshita T, Nakagawa M, Enokida H (2012). "Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma". Int. J. Oncol. 41 (3): 805–17. doi:10.3892/ijo.2012.1543. PMC 3582944. PMID 22766839.
• Ramachandran S, Karp PH, Jiang P, Ostedgaard LS, Walz AE, Fisher JT, Keshavjee S, Lennox KA, Jacobi AM, Rose SD, Behlke MA, Welsh MJ, Xing Y, McCray PB (2012). "A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator". Proc. Natl. Acad. Sci. U.S.A. 109 (33): 13362–7. Bibcode:2012PNAS..10913362R. doi:10.1073/pnas.1210906109. PMC 3421220. PMID 22853952.
• Girgis AH, Iakovlev VV, Beheshti B, Bayani J, Squire JA, Bui A, Mankaruos M, Youssef Y, Khalil B, Khella H, Pasic M, Yousef GM (2012). "Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma". Cancer Res. 72 (20): 5273–84. doi:10.1158/0008-5472.CAN-12-0656. PMID 22926558.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.