Mikkelson is a surname of Scandinavian origin. Notable people with the surname include:
- Bill Mikkelson (born 1948), retired Canadian ice hockey defenceman
- Brendan Mikkelson (born 1987), Canadian ice hockey defenceman
- Meaghan Mikkelson (born 1985), member of the 2009–10 Hockey Canada national women's team
- Tim Mikkelson (born 1986), New Zealand rugby union player
- Barbara and David Mikkelson, founders of Snopes.com, a fact-checking website