Glycylpeptide N-tetradecanoyltransferase 1

Article
Talk

(Redirected from NMT1 (gene))

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene.^[5]^[6] It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes.

NMT1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1RXT, 3IU1, 3IU2, 3IWE, 3JTK, 4C2Y, 4C2Z

Identifiers

NMT1, Nmt1, AW536594, NMT, N-myristoyltransferase 1

External IDs

OMIM: 160993; MGI: 102579; HomoloGene: 69027; GeneCards: NMT1; OMA:NMT1 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.31	Start	44,957,992 bp^[1]
Band	17q21.31	End	45,109,016 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E1	Start	102,919,016 bp^[2]
Band	11\|11 E1	End	102,959,738 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

monocyte

right adrenal gland

islet of Langerhans

sural nerve

gastrocnemius muscle

left adrenal gland

right adrenal cortex

Achilles tendon

left adrenal cortex

granulocyte

Top expressed in

Ileal epithelium

endothelial cell of lymphatic vessel

vestibular membrane of cochlear duct

Paneth cell

primitive streak

lacrimal gland

gastrula

decidua

interventricular septum

hair follicle

More reference expression data


More reference expression data

Gene ontology
Molecular function	transferase activity acyltransferase activity glycylpeptide N-tetradecanoyltransferase activity myristoyltransferase activity
Cellular component	membrane plasma membrane extrinsic component of membrane cytoplasm mitochondrion cytosol
Biological process	regulation of rhodopsin mediated signaling pathway in utero embryonic development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway N-terminal peptidyl-glycine N-myristoylation N-terminal protein myristoylation cellular ketone metabolic process
Sources:Amigo / QuickGO

Species

Human

Mouse


4836


18107


ENSG00000136448


ENSMUSG00000020936


P30419


O70310

RefSeq (mRNA)


NM_021079


NM_008707

RefSeq (protein)


NP_066565


NP_032733

Location (UCSC)

Chr 17: 44.96 – 45.11 Mb

Chr 11: 102.92 – 102.96 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020936 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duronio RJ, Reed SI, Gordon JI (May 1992). "Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 89 (9): 4129–33. Bibcode:1992PNAS...89.4129D. doi:10.1073/pnas.89.9.4129. PMC 525646. PMID 1570339.
^ "Entrez Gene: NMT1 N-myristoyltransferase 1".

Further reading

Rajala RV, Datla RS, Moyana TN, et al. (2000). "N-myristoyltransferase". Mol. Cell. Biochem. 204 (1–2): 135–55. doi:10.1023/A:1007012622030. PMID 10718634. S2CID 264010084.
Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
Wice BM, Gordon JI (1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". J. Cell Biol. 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC 2289284. PMID 1530946.
Mumby SM, Heukeroth RO, Gordon JI, Gilman AG (1990). "G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728–32. Bibcode:1990PNAS...87..728M. doi:10.1073/pnas.87.2.728. PMC 53339. PMID 2153964.
Pal R, Reitz MS, Tschachler E, et al. (1990). "Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly". AIDS Res. Hum. Retroviruses. 6 (6): 721–30. doi:10.1089/aid.1990.6.721. PMID 2194551.
Bryant M, Ratner L (1990). "Myristoylation-dependent replication and assembly of human immunodeficiency virus 1". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 523–7. Bibcode:1990PNAS...87..523B. doi:10.1073/pnas.87.2.523. PMC 53297. PMID 2405382.
Tashiro A, Shoji S, Kubota Y (1990). "Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal diethylacetal resulted in inhibition of virus production". Biochem. Biophys. Res. Commun. 165 (3): 1145–54. doi:10.1016/0006-291X(89)92722-8. PMID 2692561.
Goddard C, Aquino A, Glazer RI, Felsted RL (1989). "Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein". Eur. J. Biochem. 182 (2): 323–6. doi:10.1111/j.1432-1033.1989.tb14833.x. PMID 2737204.
Göttlinger HG, Sodroski JG, Haseltine WA (1989). "Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5781–5. Bibcode:1989PNAS...86.5781G. doi:10.1073/pnas.86.15.5781. PMC 297714. PMID 2788277.
Schultz AM, Henderson LE, Oroszlan S, et al. (1985). "Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein". Science. 227 (4685): 427–9. Bibcode:1985Sci...227..427S. doi:10.1126/science.3917576. PMID 3917576.
Liu J, Sessa WC (1994). "Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase". J. Biol. Chem. 269 (16): 11691–4. doi:10.1016/S0021-9258(17)32626-1. PMID 7512951.
Lee PP, Linial ML (1994). "Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". J. Virol. 68 (10): 6644–54. doi:10.1128/JVI.68.10.6644-6654.1994. PMC 237085. PMID 7521919.
Sigal CT, Zhou W, Buser CA, et al. (1995). "Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12253–7. doi:10.1073/pnas.91.25.12253. PMC 45415. PMID 7527558.
Zhou W, Parent LJ, Wills JW, Resh MD (1994). "Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids". J. Virol. 68 (4): 2556–69. doi:10.1128/JVI.68.4.2556-2569.1994. PMC 236733. PMID 8139035.
Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. doi:10.1016/S0021-9258(17)46711-1. PMID 8360179.
Morikawa Y, Hinata S, Tomoda H, et al. (1996). "Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding". J. Biol. Chem. 271 (5): 2868–73. doi:10.1074/jbc.271.5.2868. PMID 8576268.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Zhou W, Resh MD (1997). "Differential membrane binding of the human immunodeficiency virus type 1 matrix protein". J. Virol. 70 (12): 8540–8. doi:10.1128/JVI.70.12.8540-8548.1996. PMC 190946. PMID 8970978.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

See also

External links

Overview of all the structural information available in the PDB for UniProt: P30419 (Glycylpeptide N-tetradecanoyltransferase 1) at the PDBe-KB.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Glycylpeptide_N-tetradecanoyltransferase_1&oldid=1191420028"