NrsZ (nitrogen regulated small RNA) is a bacterial small RNA found in the opportunistic pathogen Pseudomonas aeruginosa PAO1. Its transcription is induced during nitrogen limitation by the NtrB/C two-component system (an important regulator of nitrogen assimilation and swarming motility) together with the alternative sigma factor RpoN ( a global regulator involved in nitrogen metabolism). NrsZ by activating rhlA (a gene essential for rhamnolipids synthesis) positively regulates the production of rhamnolipid surfactants needed for swarming motility.[1]
| NrsZ sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of NrsZ small RNA | |
| Identifiers | |
| Rfam | RF02695 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0071978 |
| SO | SO:0000370 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Wenner N, Maes A, Cotado-Sampayo M, Lapouge K (April 2014). "NrsZ: a novel, processed, nitrogen-dependent, small non-coding RNA that regulates Pseudomonas aeruginosa PAO1 virulence". Environmental Microbiology. 16 (4): 1053–1068. doi:10.1111/1462-2920.12272. PMC 4253122. PMID 24308329.
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |