SrbA (sRNA regulator of biofilms A) is a small regulatory non-coding RNA identified in pathogenic Pseudomonas aeruginosa[1]. It is important for biofilm formation and pathogenicity. Bacterial strain with deleted SrbA had reduced biofilm mass. As the ability to form biofilms [2] can contribute to the ability a pathogen to thrive within the host, the C. elegans hosts infected with the srbA deleted strain displayed significantly lower mortality rate than the wild-type strain. However, the deletion of srbA had no effect on growth or antibiotic resistance in P. aeruginosa.[3]
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editReferences
edit- ^ Kerr KG, Snelling AM (December 2009). "Pseudomonas aeruginosa: a formidable and ever-present adversary". The Journal of Hospital Infection. 73 (4): 338–344. doi:10.1016/j.jhin.2009.04.020. PMID 19699552.
- ^ Stewart PS, Franklin MJ (March 2008). "Physiological heterogeneity in biofilms". Nature Reviews. Microbiology. 6 (3): 199–210. doi:10.1038/nrmicro1838. PMID 18264116. S2CID 5477887.
- ^ Taylor PK, Van Kessel AT, Colavita A, Hancock RE, Mah TF (2017). "A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa". PLOS ONE. 12 (8): e0182582. doi:10.1371/journal.pone.0182582. PMC 5542712. PMID 28771593.
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