PANK1

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.

PANK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I7N, 3SMP
Identifiers
Aliases	PANK1, PANK, pantothenate kinase 1
External IDs	OMIM: 606160; MGI: 1922985; HomoloGene: 56979; GeneCards: PANK1; OMA:PANK1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.31 Start 89,582,988 bp End 89,645,242 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C1|19 Start 34,784,340 bp End 34,856,855 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa liver right lobe of liver renal medulla mucosa of colon mucosa of sigmoid colon duodenum skin of thigh rectum Top expressed in proximal tubule left lobe of liver right kidney human kidney intercostal muscle submandibular gland soleus muscle ciliary body tunica adventitia of aorta myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity ATP binding nucleotide binding transferase activity pantothenate kinase activity protein homodimerization activity acetyl-CoA binding Cellular component nucleus clathrin coat cell periphery cytosol recycling endosome cytoplasm Biological process coenzyme A biosynthetic process phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53354 75735 Ensembl ENSG00000152782 ENSMUSG00000033610 UniProt Q8TE04 Q8K4K6 RefSeq (mRNA) NM_138316 NM_148977 NM_148978 NM_001114339 NM_023792 RefSeq (protein) NP_612189 NP_683878 NP_683879 NP_001107811 NP_076281 Location (UCSC) Chr 10: 89.58 – 89.65 Mb Chr 19: 34.78 – 34.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. doi:10.1152/ajpendo.1985.248.1.E1. PMID 2981478.
• Hong BS, Senisterra G, Rabeh WM, et al. (2007). "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984–93. doi:10.1074/jbc.M701915200. PMID 17631502.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Ramaswamy G, Karim MA, Murti KG, Jackowski S (2004). "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression". J. Lipid Res. 45 (1): 17–31. doi:10.1194/jlr.M300279-JLR200. PMID 14523052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Westaway SK, Hayflick SJ, Zhou B, Gitschier JD (2003). "In reference to the Short Communication published by Ni et al". Int. J. Biochem. Cell Biol. 34 (12): 1629. doi:10.1016/S1357-2725(02)00125-5. PMID 12379284.
• Zhou B, Westaway SK, Levinson B, et al. (2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat. Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594. S2CID 20400095.