PODXL2

Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene.

PODXL2
Identifiers
Aliases	PODXL2, EG, PODLX2, podocalyxin like 2
External IDs	OMIM: 616627; MGI: 2442488; HomoloGene: 9254; GeneCards: PODXL2; OMA:PODXL2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.3 Start 127,629,185 bp End 127,672,802 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 88,842,558 bp End 88,875,044 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right hemisphere of cerebellum anterior cingulate cortex right frontal lobe ventricular zone C1 segment anterior pituitary prefrontal cortex Brodmann area 9 nucleus accumbens Top expressed in dorsomedial hypothalamic nucleus superior frontal gyrus central gray substance of midbrain primary visual cortex suprachiasmatic nucleus cerebellar cortex neural layer of retina dorsal tegmental nucleus lateral hypothalamus dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function glycosaminoglycan binding protein binding Cellular component integral component of membrane integral component of plasma membrane membrane Golgi lumen Biological process leukocyte tethering or rolling cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50512 319655 Ensembl ENSG00000114631 ENSMUSG00000033152 UniProt Q9NZ53 Q8CAE9 RefSeq (mRNA) NM_015720 NM_176973 NM_001347327 NM_001364575 RefSeq (protein) NP_056535 NP_001334256 NP_795947 NP_001351504 NP_001366146 NP_001366147 NP_001366148 NP_001366149 NP_001366150 NP_001366151 NP_001366152 Location (UCSC) Chr 3: 127.63 – 127.67 Mb Chr 6: 88.84 – 88.88 Mb PubMed search
Wikidata
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Structure

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].

Function

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins

Further reading

• Fieger CB, Sassetti CM, Rosen SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x". J. Biol. Chem. 278 (30): 27390–8. doi:10.1074/jbc.M304204200. PMID 12889478.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.