Poly(adp-ribose) polymerase family member 14

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene.

PARP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4
Identifiers
Aliases	PARP14, ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14
External IDs	OMIM: 610028; MGI: 1919489; HomoloGene: 19697; GeneCards: PARP14; OMA:PARP14 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.1 Start 122,680,839 bp End 122,730,840 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 35,653,244 bp End 35,691,914 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve nasal epithelium Achilles tendon white blood cell monocyte spleen granulocyte decidua appendix lymph node Top expressed in intestinal villus Paneth cell epithelium of small intestine lymph node jejunum mesenteric lymph nodes lumbar spinal ganglion mucous cell of stomach white pulp conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity RNA binding protein binding NAD+ binding NAD+ ADP-ribosyltransferase activity enzyme binding protein ADP-ribosylase activity Cellular component membrane nucleus cytosol cytoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated protein poly-ADP-ribosylation protein ADP-ribosylation negative regulation of gene expression positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein negative regulation of interferon-gamma-mediated signaling pathway positive regulation of interleukin-4-mediated signaling pathway immune system process innate immune response protein mono-ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54625 547253 Ensembl ENSG00000173193 ENSMUSG00000034422 UniProt Q460N5 Q8N546 Q2EMV9 RefSeq (mRNA) NM_017554 NM_001039530 RefSeq (protein) NP_060024 NP_060024.2 NP_001034619 Location (UCSC) Chr 3: 122.68 – 122.73 Mb Chr 16: 35.65 – 35.69 Mb PubMed search
Wikidata
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Function

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.