April 25
- 1880 – Much of the western part of Macon, Mississippi was destroyed by an F4 tornado. Twenty-two people, including several entire families, were killed. Railroad equipment and loaded freight cars were thrown up to 100 yards.
- 1893 – An F4 tornado up to 1.25 miles (2.01 km) wide moved through Newcastle and Moore, Oklahoma, killing 31 people, including 11 in one home. Many homes of light construction were swept away. This was the first of several devastating storms to strike Moore in its long history of major tornadoes.
- 1929 – The most significant tornado on record in southeastern Georgia killed at least 40 people as it swept away homes in Emanuel, Candler, and Bulloch Counties. The path of the F4 tornado was, at times a mile (1.6 km) wide.