April 27
- 1942 – An F4 tornado destroyed about a third of Pryor, Oklahoma, killing 52 people. Many of the homes destroyed had been hastily built during the town's wartime expansion.
- 2011 – The peak of the 2011 Super Outbreak saw 216 tornadoes produced in 24 hours across the Southeastern United States. Four EF5s and eleven EF4s were among the tornadoes that devastated parts of Mississippi, Alabama, Tennessee, and Georgia. The death toll on April 27 was 319. For the entire outbreak, 360 tornadoes occurred over four days, resulting in 324 fatalities.