April 5
- 1907 – A tornado outbreak killed at least 23 people in Louisiana and Alabama. The greatest loss of life was from an F3 tornado that killed 13 people in West and East Feliciana parishes, including 4 at a mental institute near Jackson, Louisiana. An F2 tornado killed 4 people in Alexandria, Louisiana and an F3 tornado killed 3 (possibly 7) people near Patsburg, Alabama.
- 1936 – An F5 tornado, one of the deadliest in United States history, devastated Tupelo, Mississippi, killing at least 216 people, with reports of up to 233 deaths. The death toll may have been higher, as the fate of many African American victims is not well-documented.
- 1972 – An F3 tornado caused significant damage in Portland, Oregon and Vancouver, Washington, killing six people and injuring more than 300. Five people were killed by the collapsing walls of a store. About 150 students were injured by glass in an elementary school. The F3 rating is disputed.