RAP2B

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. RAP2B belongs to the Ras-related protein family.

RAP2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4P, 1N4Q, 1N4R, 1N4S
Identifiers
Aliases	RAP2B, member of RAS oncogene family
External IDs	OMIM: 179541; MGI: 1921262; HomoloGene: 55701; GeneCards: RAP2B; OMA:RAP2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.2 Start 153,162,226 bp End 153,170,627 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 E1 Start 61,269,059 bp End 61,275,851 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium germinal epithelium buccal mucosa cell amniotic fluid tendon of biceps brachii mucosa of pharynx hair follicle human penis palpebral conjunctiva secondary oocyte Top expressed in aortic valve cumulus cell ascending aorta epithelium of lens lumbar subsegment of spinal cord Rostral migratory stream tibiofemoral joint calvaria external carotid artery dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein domain specific binding GDP binding GTP binding protein binding GTPase activity Cellular component recycling endosome cytosol endosome membrane cell-cell contact zone bicellular tight junction recycling endosome membrane membrane raft extracellular exosome plasma membrane specific granule membrane tertiary granule membrane Biological process regulation of protein tyrosine kinase activity microvillus assembly establishment of endothelial intestinal barrier Rap protein signal transduction platelet activation negative regulation of cell migration positive regulation of protein autophosphorylation platelet aggregation signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5912 74012 Ensembl ENSG00000181467 ENSMUSG00000036894 UniProt P61225 P61226 RefSeq (mRNA) NM_002886 NM_028712 RefSeq (protein) NP_002877 NP_082988 Location (UCSC) Chr 3: 153.16 – 153.17 Mb Chr 3: 61.27 – 61.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.

Further reading

• Farrell FX, Ohmstede CA, Reep BR, Lapetina EG (1990). "cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2". Nucleic Acids Res. 18 (14): 4281. doi:10.1093/nar/18.14.4281. PMC 331220. PMID 2115998.
• Pizon V, Chardin P, Lerosey I, et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.
• Torti M, Ramaschi G, Sinigaglia F, et al. (1993). "Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7553–7. Bibcode:1993PNAS...90.7553T. doi:10.1073/pnas.90.16.7553. PMC 47180. PMID 8356055.
• Mollinedo F, Perez-Sala D, Gajate C, et al. (1993). "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils". FEBS Lett. 326 (1–3): 209–14. doi:10.1016/0014-5793(93)81792-X. PMID 8391995. S2CID 6867463.
• Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". Biochem. J. 289 ( Pt 2) (Pt 2): 349–55. doi:10.1042/bj2890349. PMC 1132174. PMID 8424780.
• Nancy V, Wolthuis RM, de Tand MF, et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
• Evellin S, Nolte J, Tysack K, et al. (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.
• Song C, Satoh T, Edamatsu H, et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Greco F, Sinigaglia F, Balduini C, Torti M (2005). "Activation of the small GTPase Rap2B in agonist-stimulated human platelets". J. Thromb. Haemost. 2 (12): 2223–30. doi:10.1111/j.1538-7836.2004.01018.x. PMID 15613030. S2CID 25336596.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu Y, Sun W, Zhang K, et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma". Lung Cancer. 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID 17316888.