Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene .[ 5] [ 6] [ 7]
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein . The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer , which is caused by the methylation of its promoter and CpG island . Alternatively spliced transcript variant encoding distinct isoforms have been observed.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000118849 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049404 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (May 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin" . J Invest Dermatol . 106 (2): 269–74. doi :10.1111/1523-1747.ep12340668 PMID 8601727 . ^ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol . 37 (2 Pt 3): S18–24. doi :10.1016/s0190-9622(97)80396-9 . PMID 9270552 . ^ a b "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1" .
Jing C, El-Ghany MA, Beesley C, et al. (2002). "Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity" . J. Natl. Cancer Inst . 94 (7): 482–90. doi :10.1093/jnci/94.7.482 PMID 11929948 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Zhang J, Liu L, Pfeifer GP (2004). "Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene" . Oncogene . 23 (12): 2241–9. doi :10.1038/sj.onc.1207328 PMID 14691453 . Youssef EM, Chen XQ, Higuchi E, et al. (2004). "Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers" . Cancer Res . 64 (7): 2411–7. doi :10.1158/0008-5472.CAN-03-0164 PMID 15059893 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Mizuiri H, Yoshida K, Toge T, et al. (2005). "DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage" . Cancer Sci . 96 (9): 571–7. doi :10.1111/j.1349-7006.2005.00082.x PMC 11159114 PMID 16128742 . S2CID 39812145 . Shutoh M, Oue N, Aung PP, et al. (2006). "DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation" . Cancer . 104 (8): 1609–19. doi :10.1002/cncr.21392 PMID 16134180 . S2CID 43346140 .
