Sec61 alpha 1

Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.

SEC61A1
Identifiers
Aliases	SEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5
External IDs	OMIM: 609213; MGI: 1858417; HomoloGene: 55537; GeneCards: SEC61A1; OMA:SEC61A1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.3 Start 128,051,641 bp End 128,071,683 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 88,480,561 bp End 88,495,887 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas stromal cell of endometrium islet of Langerhans anterior pituitary right lobe of liver smooth muscle tissue body of stomach left adrenal gland upper lobe of left lung left adrenal cortex Top expressed in internal carotid artery Ileal epithelium external carotid artery Paneth cell utricle ascending aorta seminal vesicula crypt of lieberkuhn of small intestine lacrimal gland aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ribosome binding signal sequence binding protein transmembrane transporter activity calcium channel activity Cellular component integral component of membrane cytosol rough endoplasmic reticulum integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Sec61 translocon complex Biological process response to interferon-gamma endoplasmic reticulum organization SRP-dependent cotranslational protein targeting to membrane posttranslational protein targeting to endoplasmic reticulum membrane protein targeting to ER protein transport pronephric nephron development cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane, translocation calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29927 53421 Ensembl ENSG00000058262 ENSMUSG00000030082 UniProt P61619 P61620 RefSeq (mRNA) NM_013336 NM_001400328 NM_001400329 NM_016906 RefSeq (protein) NP_037468 NP_058602 Location (UCSC) Chr 3: 128.05 – 128.07 Mb Chr 6: 88.48 – 88.5 Mb PubMed search
Wikidata
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The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.

Further reading

• Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469. S2CID 6276718.
• Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (1): 161–7. doi:10.1042/bj3310161. PMC 1219334. PMID 9512475.
• Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
• Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. doi:10.1074/jbc.273.45.29873. PMID 9792704.
• Greenfield JJ; High S (1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J. Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
• Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation". J. Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC 2168098. PMID 10601334.
• Petaja-Repo UE, Hogue M, Laperriere A, et al. (2001). "Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome". J. Biol. Chem. 276 (6): 4416–23. doi:10.1074/jbc.M007151200. PMID 11054417.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.