Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.[5]

SEC61A1
Identifiers
AliasesSEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5
External IDsOMIM: 609213; MGI: 1858417; HomoloGene: 55537; GeneCards: SEC61A1; OMA:SEC61A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013336
NM_001400328
NM_001400329

NM_016906

RefSeq (protein)

NP_037468

NP_058602

Location (UCSC)Chr 3: 128.05 – 128.07 MbChr 6: 88.48 – 88.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058262Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030082Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)".

Further reading

edit