Senator Vance may refer to:
- Elijah Vance (1801–1871), Ohio State Senate
- JD Vance (born 1984), U.S. Senator from Ohio
- Joseph Vance (Ohio politician) (1786–1852), Ohio State Senate
- Pat Vance (born 1936), Pennsylvania State Senate
- William R. Vance (1806–1885), Kentucky State Senate
- William Washington Vance (1849–1900), Louisiana State Senate
- Zebulon Baird Vance (1830–1894), U.S. Senator from North Carolina