Speke may refer to:
- John Hanning Speke, British explorer of Africa
- Speke is a district in Liverpool, England
- Speke (surname)
- Mount Speke, a mountain in the Ruwenzori Range, Uganda
- PS Speke, a Uganda Railway paddle steamer named after John Hanning Speke
- SPEKE (cryptography) (Simple Password Exponential Key Exchange), cryptographic protocol
- Speke baronets
- Speke (ship), a number of ships with the same name
This disambiguation page lists articles associated with the title Speke.
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