In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.[3]
| SprX sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of SprX small RNA | |
| Identifiers | |
| Rfam | RF02672 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0040033 |
| SO | SO:0000370 |
| PDB structures | PDBe |
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See also
editReferences
edit- ^ Bohn C, Rigoulay C, Chabelskaya S, Sharma CM, Marchais A, Skorski P, Borezée-Durant E, Barbet R, Jacquet E, Jacq A, Gautheret D, Felden B, Vogel J, Bouloc P (October 2010). "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". Nucleic Acids Research. 38 (19): 6620–36. doi:10.1093/nar/gkq462. PMC 2965222. PMID 20511587.
- ^ Eyraud A, Tattevin P, Chabelskaya S, Felden B (April 2014). "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". Nucleic Acids Research. 42 (8): 4892–905. doi:10.1093/nar/gku149. PMC 4005690. PMID 24557948.
- ^ Kathirvel M, Buchad H, Nair M (December 2016). "Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1". Medical Microbiology and Immunology. 205 (6): 563–574. doi:10.1007/s00430-016-0467-9. PMID 27438010. S2CID 15284645.
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