Susan Diana Brain FBPhS is a professor of pharmacology at the School of Cardiovascular Medicine and Sciences at King's College London where she has worked since 1989.[1]
Susan Brain | |
|---|---|
| Born | Susan Diana Brain |
| Alma mater | University of London (PhD) |
| Scientific career | |
| Fields | Physiology Pharmacology |
| Institutions | King's College London |
| Thesis | Relationship between lipolysis and prostaglandin biosynthesis in adipose tissue (1981) |
| Website | www |
Education
editBrain completed a PhD in pharmacology at University College London in 1981.
Career and research
editBrain held a postdoctoral post at the Institute of Dermatology. In 1989 she took up a lectureship at King's College London, where she was promoted to Reader in 1993[2] and in 1998 she was made Professor of Pharmacology at the School of Cardiovascular Medicine, where since 2005 she has been Head of the Vascular Biology and Inflammation Section.[3] She was also Head of the Pharmacology and Therapeutics Education Department between 2011 and 2018.
Brain's research investigates the role of sensory nerves in vascular inflammation.[4] In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular vasodilator.[5] More recently her research found that the gene TRPC5 can help protect against pain in arthritis[6] and that the gene TRPA1 is essential for the vascular response when being exposed to cold environments.[7]
Awards and honours
editIn 2018 she was elected as honorary fellow of the British Pharmacological Society.[8]
References
edit- ^ Susan Brain's ORCID 0000-0002-9684-8342
- ^ "Susan Brain – CGRP Education & Research Forum". 20 March 2017. Retrieved 17 October 2019.
- ^ "Professor Susan Brain". www.kcl.ac.uk. Archived from the original on 17 October 2019. Retrieved 17 October 2019.
- ^ Sousa-Valente, João; Brain, Susan D. (2018). "A historical perspective on the role of sensory nerves in neurogenic inflammation". Seminars in Immunopathology. 40 (3): 229–236. doi:10.1007/s00281-018-0673-1. ISSN 1863-2297. PMC 5960476. PMID 29616309.
- ^ Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a potent vasodilator". Nature. 313 (5997): 54–56. doi:10.1038/313054a0. ISSN 0028-0836. PMID 3917554. S2CID 4329128.
- ^ Alawi, Khadija M; Russell, Fiona A; Aubdool, Aisah A; Srivastava, Salil; Riffo-Vasquez, Yanira; Baldissera, Lineu; Thakore, Pratish; Saleque, Nurjahan; Fernandes, Elizabeth S; Walsh, David A; Brain, Susan D (2017). "Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation". Annals of the Rheumatic Diseases. 76 (1): 252–260. doi:10.1136/annrheumdis-2015-208886. ISSN 0003-4967. PMC 5264234. PMID 27165180.
- ^ Aubdool, Aisah A.; Graepel, Rabea; Kodji, Xenia; Alawi, Khadija M.; Bodkin, Jennifer V.; Srivastava, Salil; Gentry, Clive; Heads, Richard; Grant, Andrew D.; Fernandes, Elizabeth S.; Bevan, Stuart (2014). "TRPA1 is essential for the vascular response to environmental cold exposure". Nature Communications. 5 (1): 5732. doi:10.1038/ncomms6732. ISSN 2041-1723. PMC 4284811. PMID 25501034.
- ^ "Professor Susan Brain, Honorary Fellows". British Pharmacological Society. Archived from the original on 17 October 2019. Retrieved 17 October 2019.