Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.[5][6][7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.
Function
editTrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na+–H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).[5]
TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity[8] and neurological behavior.[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.[10]
Activation
editHomomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.[11] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.[12]
Interactions
editTRPC5 has been shown to interact with STMN3,[13] TRPC1,[14][15] and TRPC4.[15]
See also
editReferences
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: transient receptor potential cation channel".
- ^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, et al. (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–340. doi:10.1006/geno.1999.5924. PMID 10493832.
- ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
- ^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B (January 2012). "Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure". Toxicological Sciences. 125 (1): 56–68. doi:10.1093/toxsci/kfr268. PMID 21984481.
- ^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, et al. (May 2009). "Essential role for TRPC5 in amygdala function and fear-related behavior". Cell. 137 (4): 761–772. doi:10.1016/j.cell.2009.03.039. PMC 2719954. PMID 19450521.
- ^ Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, et al. (March 2021). "Odontoblast TRPC5 channels signal cold pain in teeth". Science Advances. 7 (13): eabf5567. Bibcode:2021SciA....7.5567B. doi:10.1126/sciadv.abf5567. PMC 7997515. PMID 33771873.
- ^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, et al. (January 2008). "TRPC channel activation by extracellular thioredoxin". Nature. 451 (7174): 69–72. Bibcode:2008Natur.451...69X. doi:10.1038/nature06414. PMC 2645077. PMID 18172497.
- ^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, et al. (April 2008). "Modulation of TRPC5 cation channels by halothane, chloroform and propofol". British Journal of Pharmacology. 153 (7): 1505–1512. doi:10.1038/sj.bjp.0707689. PMC 2437913. PMID 18204473.
- ^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience. 6 (8): 837–845. doi:10.1038/nn1092. PMID 12858178. S2CID 7523946.
- ^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". The Journal of Biological Chemistry. 278 (40): 39014–39019. doi:10.1074/jbc.M306705200. PMID 12857742.
- ^ a b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7461–7466. Bibcode:2002PNAS...99.7461H. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305.
Further reading
edit- Beech DJ (2007). "Canonical transient receptor potential 5". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 109–23. doi:10.1007/978-3-540-34891-7_6. ISBN 978-3-540-34889-4. PMID 17217053.
- Beech DJ (February 2007). "Bipolar phospholipid sensing by TRPC5 calcium channel". Biochemical Society Transactions. 35 (Pt 1): 101–104. doi:10.1042/BST0350101. PMID 17233612.
External links
edit- TRPC5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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