KCNK5

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.

KCNK5
Identifiers
Aliases	KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDs	OMIM: 603493; MGI: 1336175; HomoloGene: 2773; GeneCards: KCNK5; OMA:KCNK5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.2 Start 39,188,971 bp End 39,229,475 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A3 Start 20,190,125 bp End 20,231,877 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of transverse colon mucosa of ileum oocyte duodenum human kidney kidney tubule secondary oocyte jejunal mucosa skin of leg Top expressed in right kidney proximal tubule intestinal villus human kidney left colon jejunum lumbar spinal ganglion pyloric antrum morula duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated potassium channel activity potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity Cellular component integral component of membrane integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport excretion ion transport potassium ion transmembrane transport stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8645 16529 Ensembl ENSG00000164626 ENSMUSG00000023243 UniProt O95279 Q9JK62 RefSeq (mRNA) NM_003740 NM_021542 RefSeq (protein) NP_003731 NP_067517 Location (UCSC) Chr 6: 39.19 – 39.23 Mb Chr 14: 20.19 – 20.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gray AT, Zhao BB, Kindler CH, et al. (2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5". Anesthesiology. 92 (6): 1722–30. doi:10.1097/00000542-200006000-00032. PMID 10839924. S2CID 45487917.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Morton MJ, O'Connell AD, Sivaprasadarao A, Hunter M (2003). "Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2". Pflügers Arch. 445 (5): 577–83. doi:10.1007/s00424-002-0901-2. PMID 12634929. S2CID 6338907.
• Niemeyer MI, Cid LP, Valenzuela X, et al. (2004). "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity". Mol. Membr. Biol. 20 (2): 185–91. doi:10.1080/0968768031000084181. hdl:10533/174402. PMID 12851074. S2CID 36255147.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMC 11138546. PMID 15197476. S2CID 11439105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• KCNK5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.